RhoA orchestrates glycolysis for TH2 cell differentiation and allergic airway inflammation.

ABSTRACT:

Background

Mitochondrial metabolism is known to be important for T-cell activation. However, its involvement in effector T-cell differentiation has just begun to gain attention. Importantly, how metabolic pathways are integrated with T-cell activation and effector cell differentiation and function remains largely unknown.

Objective

We sought to test our hypothesis that RhoA GTPase orchestrates glycolysis for TH2 cell differentiation and TH2-mediated allergic airway inflammation.

Methods

Conditional RhoA-deficient mice were generated by crossing RhoA(flox/flox) mice with CD2-Cre transgenic mice. Effects of RhoA on TH2 differentiation were evaluated based on in vitro TH2-polarized culture conditions and in vivo in ovalbumin-induced allergic airway inflammation. Cytokine

SUBMITTER: Yang JQ 

PROVIDER: S-EPMC4684821 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature