Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33.

ABSTRACT:

Background

Rhinovirus infection at an early age has been associated with development of asthma, but how rhinovirus influences the immune response is not clear.

Objective

Tolerance to inhaled antigen is mediated through induction of regulatory T (Treg) cells, and we examined whether rhinovirus infection of the respiratory tract can block airway tolerance by modulating Treg cells.

Methods

The immune response to intranasal ovalbumin in mice was assessed with concomitant infection with RV1B, and the factors induced in vivo were compared with those made by human lung epithelial cells infected in vitro with RV16.

Results

RV1B infection of mice abrogated tolerance induced by inhalation of soluble ovalbumin, suppressing the normal generation of forkhead box protein 3-p

SUBMITTER: Mehta AK 

PROVIDER: S-EPMC4684822 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature