Sex difference of autosomal alleles in populations of European and African descent.

ABSTRACT: In the present study, we aimed to report the individual sex-different genetic markers across autosomes in European- and African-origin populations. A total of 8,400 females and 8,081 males in 19 independent cohorts were genotyped across genomes using Illumina or Affymetrix arrays. The allele frequencies were compared between females and males in 9 non-clean cohorts (with some human disease traits) using genome-wide logistic regression and then the nominally significant associations were replicated across 10 clean cohorts (without disease traits). Meta-analysis was performed to derive the combined p values across all cohorts. We found 13 markers that were genome-wide significant (p≤5×10^-8) between females and males in the meta-analysis of all cohorts of European descent, includin

SUBMITTER: Zuo L 

PROVIDER: S-EPMC4684836 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature