Evolutionary context for the association of γ-globin, serum uric acid, and hypertension in African Americans.

ABSTRACT:

Background

Hyperuricemia and associated cardio-metabolic disorders are more prevalent in African Americans than in European Americans. We used genome-wide admixture mapping and association testing to identify loci with ancestry effects on serum uric acid levels.

Methods

We analyzed 1,976 African Americans from Washington, D.C, including 1,322 individuals from 328 pedigrees and 654 unrelated individuals, enrolled in the Howard University Family Study. We performed admixture mapping and genome-wide association testing using ~800 k autosomal single-nucleotide polymorphisms (SNPs). We performed fine mapping by dense genotyping. We assessed functionality by a combination of bioinformatic annotation, reporter gene assays, and gel shift experiments. We also analyzed 12,641 individu

SUBMITTER: Shriner D 

PROVIDER: S-EPMC4684912 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature