A randomized phase II study of radiation induced immune boost in operable non-small cell lung cancer (RadImmune trial).

ABSTRACT:

Background

Lung cancer is the leading cause of cancer deaths worldwide. Surgery, radiotherapy at conventional and high dose and chemotherapy are the mainstay for lung cancer treatment. Insufficient migration and activation of tumour specific effector T cells seem to be important reasons for inadequate host anti-tumour immune response. Ionizing radiation can induce a variety of immune responses. The goal of this randomized trial is to assess if a preoperative single fraction low dose radiation is able to improve anti-tumour immune response in operable early stage lung cancer.

Methods/design

This trial has been designed as an investigator-initiated, prospective, randomized, 2-armed phase II trial. Patients who are candidates for elective resection of early stage non-small cell

SUBMITTER: Safi S 

PROVIDER: S-EPMC4684916 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature