Resting-state functional network connectivity in prefrontal regions differs between unmedicated patients with bipolar and major depressive disorders.

ABSTRACT:

Background

Differentiating bipolar disorder (BD) from major depressive disorder (MDD) often poses a major clinical challenge, and optimal clinical care can be hindered by misdiagnoses. This study investigated the differences between BD and MDD in resting-state functional network connectivity (FNC) using a data-driven image analysis method.

Methods

In this study, fMRI data were collected from unmedicated subjects including 13 BD, 40 MDD and 33 healthy controls (HC). The FNC was calculated between functional brain networks derived from fMRI using group independent component analysis (ICA). Group comparisons were performed on connectivity strengths and other graph measures of FNC matrices.

Results

Statistical tests showed that, compared to MDD, the FNC in BD was characte

SUBMITTER: He H 

PROVIDER: S-EPMC4684976 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature