Creatine as a Novel Treatment for Depression in Females Using Methamphetamine: A Pilot Study.

ABSTRACT:

Objective

Depression among methamphetamine users is more prevalent in females than males, but gender-specific treatment options for this comorbidity have not been described. Reduced brain phosphocreatine levels have been shown to be lower in female methamphetamine users compared to males, and, of relevance, studies have demonstrated an association between treatment-resistant depression and reduced brain phosphocreatine concentrations. The nutritional supplement creatine monohydrate has been reported to reduce symptoms of depression in female adolescents and adults taking antidepressants, as well as to increase brain phosphocreatine in healthy volunteers. Therefore, the purpose of this pilot study was to investigate creatine monohydrate as a treatment for depression in female metham

SUBMITTER: Hellem TL 

PROVIDER: S-EPMC4684979 | biostudies-literature | 2015 Jul-Dec

REPOSITORIES: biostudies-literature