Haptoglobin gene polymorphisms and interleukin-6 and -8 levels in patients with sickle cell anemia.

ABSTRACT:

Background

Haptoglobin genotypes, and interleukin-6 and -8 participate in the pathophysiology of sickle cell anemia. The expression of cytokines is regulated by genetic mechanisms however the effect of haptoglobin polymorphisms on these cytokines is not fully understood. This study aimed to compare the frequency of haptoglobin genotypes and the interleukin-6 and -8 concentrations in sickle cell anemia patients and controls to investigate the association between haptoglobin genotypes and cytokine levels.

Methods

Sixty sickle cell anemia patients and 74 healthy individuals were analyzed. Haptoglobin genotypes were determined by multiplex polymerase chain reaction, and the interleukin-6 and -8 levels by enzyme linked immunosorbent assay. The association between haptoglobin geno

SUBMITTER: Pierrot-Gallo BS 

PROVIDER: S-EPMC4685105 | biostudies-literature | 2015 Sep-Oct

REPOSITORIES: biostudies-literature