Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events.

ABSTRACT:

Background

The ankle brachial index (ABI) is related to risk of cardiovascular events independent of the Framingham risk score (FRS). The aim of this study was to develop and evaluate a risk model for cardiovascular events incorporating the ABI and FRS.

Design

An analysis of participant data from 18 cohorts in which 24,375 men and 20,377 women free of coronary heart disease had ABI measured and were followed up for events.

Methods

Subjects were divided into a development and internal validation dataset and an external validation dataset. Two models, comprising FRS and FRS + ABI, were fitted for the primary outcome of major coronary events.

Results

In predicting events in the external validation dataset, C-index for the FRS was 0.672 (95% CI 0.599 to 0.737) in m

SUBMITTER: Fowkes FG 

PROVIDER: S-EPMC4685459 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature