Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.

ABSTRACT:

Background

Protein post-translational modifications (PTMs) are an important aspect of protein regulation. The number of PTMs discovered within the human proteome, and other proteomes, has been rapidly expanding in recent years. As a consequence of the rate in which new PTMs are identified, analysis done in one year may result in different conclusions when repeated in subsequent years. Among the various functional questions pertaining to PTMs, one important relationship to address is the interplay between modifications and mutations. Specifically, because the linear sequence surrounding a modification site often determines molecular recognition, it is hypothesized that mutations near sites of PTMs may be more likely to result in a detrimental effect on protein function, resulting in

SUBMITTER: Holehouse AS 

PROVIDER: S-EPMC4685989 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature