Beyond Axillary Lymph Node Metastasis, BMI and Menopausal Status Are Prognostic Determinants for Triple-Negative Breast Cancer Treated by Neoadjuvant Chemotherapy.

ABSTRACT:

Background

Triple-negative breast cancers (TNBC) are a specific subtype of breast cancers with a particularly poor prognosis. However, it is a very heterogeneous subgroup in terms of clinical behavior and sensitivity to systemic treatments. Thus, the identification of risk factors specifically associated with those tumors still represents a major challenge. A therapeutic strategy increasingly used for TNBC patients is neoadjuvant chemotherapy (NAC). Only a subset of patients achieves a pathologic complete response (pCR) after NAC and have a better outcome than patients with residual disease.

Purpose

The aim of this study is to identify clinical factors associated with the metastatic-free survival in TNBC patients who received NAC.

Methods

We analyzed 326 cT1-3N1-3M0 p

SUBMITTER: Bonsang-Kitzis H 

PROVIDER: S-EPMC4686172 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature