Prognostic Indications of Elevated MCT4 and CD147 across Cancer Types: A Meta-Analysis.

ABSTRACT:

Background

Metabolism in the tumor microenvironment can play a critical role in tumorigenesis and tumor aggression. Metabolic coupling may occur between tumor compartments; this phenomenon can be prognostically significant and may be conserved across tumor types. Monocarboxylate transporters (MCTs) play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. The transporters MCT1 and MCT4 are regulated via expression of their chaperone, CD147.

Methods

We conducted a meta-analysis of existing publications on the relationship between MCT1, MCT4, and CD147 expression and overall survival and disease-free survival in cancer, using hazard ratios derived via multivariate Cox regression analyses.

Results

Increase

SUBMITTER: Bovenzi CD 

PROVIDER: S-EPMC4686628 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature