Emulsions Made of Oils from Seeds of GM Flax Protect V79 Cells against Oxidative Stress.

ABSTRACT: Polyunsaturated fatty acids, sterols, and hydrophilic phenolic compounds are components of flax oil that act as antioxidants. We investigated the impact of flax oil from transgenic flax in the form of emulsions on stressed Chinese hamster pulmonary fibroblasts. We found that the emulsions protect V79 cells against the H2O2 and the effect is dose dependent. They reduced the level of intracellular reactive oxygen species and protected genomic DNA against damage. The rate of cell proliferation increased upon treatment with the emulsions at a low concentration, while at a high concentration it decreased significantly, accompanied by increased frequency of apoptotic cell death. Expression analysis of selected genes revealed the upregulatory impact of the emulsions on the histones, acetylases, a

SUBMITTER: Skorkowska-Telichowska K 

PROVIDER: S-EPMC4686677 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature