Temporal and spatial dynamics of scaling-specific features of a gene regulatory network in Drosophila.

ABSTRACT: A widely appreciated aspect of developmental robustness is pattern formation in proportion to size. But how such scaling features emerge dynamically remains poorly understood. Here we generate a data set of the expression profiles of six gap genes in Drosophila melanogaster embryos that differ significantly in size. Expression patterns exhibit size-dependent dynamics both spatially and temporally. We uncover a dynamic emergence of under-scaling in the posterior, accompanied by reduced expression levels of gap genes near the middle of large embryos. Simulation results show that a size-dependent Bicoid gradient input can lead to reduced Krüppel expression that can have long-range and dynamic effects on gap gene expression in the posterior. Thus, for emergence of scaled patterns, the entire e

SUBMITTER: Wu H 

PROVIDER: S-EPMC4686680 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature