Applications of stable, nonradioactive isotope tracers in in vivo human metabolic research.

ABSTRACT: The human body is in a constant state of turnover, that is, being synthesized, broken down and/or converted to different compounds. The dynamic nature of in vivo kinetics of human metabolism at rest and in stressed conditions such as exercise and pathophysiological conditions such as diabetes and cancer can be quantitatively assessed with stable, nonradioactive isotope tracers in conjunction with gas or liquid chromatography mass spectrometry and modeling. Although measurements of metabolite concentrations have been useful as general indicators of one's health status, critical information on in vivo kinetics of metabolites such as rates of production, appearance or disappearance of metabolites are not provided. Over the past decades, stable, nonradioactive isotope tracers have been used to

SUBMITTER: Kim IY 

PROVIDER: S-EPMC4686699 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature