Structural and Energetic Characterization of the Ankyrin Repeat Protein Family.

ABSTRACT: Ankyrin repeat containing proteins are one of the most abundant solenoid folds. Usually implicated in specific protein-protein interactions, these proteins are readily amenable for design, with promising biotechnological and biomedical applications. Studying repeat protein families presents technical challenges due to the high sequence divergence among the repeating units. We developed and applied a systematic method to consistently identify and annotate the structural repetitions over the members of the complete Ankyrin Repeat Protein Family, with increased sensitivity over previous studies. We statistically characterized the number of repeats, the folding of the repeat-arrays, their structural variations, insertions and deletions. An energetic analysis of the local frustration patterns r

SUBMITTER: Parra RG 

PROVIDER: S-EPMC4687027 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature