Advances in allergen-microarray technology for diagnosis and monitoring of allergy: the MeDALL allergen-chip.

ABSTRACT: Allergy diagnosis based on purified allergen molecules provides detailed information regarding the individual sensitization profile of allergic patients, allows monitoring of the development of allergic disease and of the effect of therapies on the immune response to individual allergen molecules. Allergen microarrays contain a large variety of allergen molecules and thus allow the simultaneous detection of allergic patients' antibody reactivity profiles towards each of the allergen molecules with only minute amounts of serum. In this article we summarize recent progress in the field of allergen microarray technology and introduce the MeDALL allergen-chip which has been developed for the specific and sensitive monitoring of IgE and IgG reactivity profiles towards more than 170 allergen mol

SUBMITTER: Lupinek C 

PROVIDER: S-EPMC4687054 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature