Differentially Expressed Genes and Signature Pathways of Human Prostate Cancer.

ABSTRACT: Genomic technologies including microarrays and next-generation sequencing have enabled the generation of molecular signatures of prostate cancer. Lists of differentially expressed genes between malignant and non-malignant states are thought to be fertile sources of putative prostate cancer biomarkers. However such lists of differentially expressed genes can be highly variable for multiple reasons. As such, looking at differential expression in the context of gene sets and pathways has been more robust. Using next-generation genome sequencing data from The Cancer Genome Atlas, differential gene expression between age- and stage- matched human prostate tumors and non-malignant samples was assessed and used to craft a pathway signature of prostate cancer. Up- and down-regulated genes were ass

SUBMITTER: Myers JS 

PROVIDER: S-EPMC4687717 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature