Chronic intermittent toluene inhalation in adolescent rats results in metabolic dysfunction with altered glucose homeostasis.

ABSTRACT:

Background and purpose

Abuse of toluene-containing inhalants is an increasing public health problem, especially among adolescents. Abuse during adolescence is associated with emaciation, while industrial exposure leads to altered glycaemic control suggesting metabolic instability. However, the relationship between adolescent inhalant abuse and metabolic dysfunction remains unknown.

Experimental approach

To model human abuse patterns, we exposed male adolescent Wistar rats [postnatal day (PND) 27] to chronic intermittent inhaled toluene (CIT, 10,000 ppm) or air (control) for 1 h·day(-1) , three times a week for 4 weeks. Feeding and body composition were monitored. After 4 weeks, circulating metabolic hormone concentrations and responses to a glucose tolerance test (GTT) were

SUBMITTER: Dick AL 

PROVIDER: S-EPMC4687795 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature