Early treatment with atorvastatin exerts parenchymal and vascular protective effects in experimental cerebral ischaemia.

ABSTRACT:

Background and purpose

From the clinical and experimental data available, statins appear to be interesting drug candidates for preventive neuroprotection in ischaemic stroke. However, their acute protective effect is, as yet, unconfirmed.

Experimental approach

Male C57Bl6/JRj mice were subjected to middle cerebral artery occlusion and treated acutely with atorvastatin (10-20 mg·kg(-1) day(-1) ; 24 or 72 h). Functional recovery (neuroscore, forelimb gripping strength and adhesive removal test) was assessed during follow-up and lesion volume measured at the end. Vasoreactivity of the middle cerebral artery (MCA), type IV collagen and FITC-dextran distribution were evaluated to assess macrovascular and microvascular protection. Activated microglia, leucocyte adhesion and infilt

SUBMITTER: Potey C 

PROVIDER: S-EPMC4687798 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature