Quantifying the value of biomarkers for predicting mortality.

ABSTRACT:

Purpose

In light of widespread interest in the prognostic value of biomarkers, we apply three discrimination measures to evaluate the incremental value of biomarkers--beyond self-reported measures--for predicting all-cause mortality. We assess whether all three measures--area under the receiver-operating characteristic curve, continuous net reclassification improvement, and integrated discrimination improvement--lead to the same conclusions.

Methods

We use longitudinal data from a nationally representative sample of older Taiwanese (n = 639, aged 54 or older in 2000, examined in 2000 and 2006, with mortality follow-up through 2011). We estimate age-specific mortality using a Gompertz hazard model.

Results

The broad conclusions are consistent across the three discrimin

SUBMITTER: Goldman N 

PROVIDER: S-EPMC4688113 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature