Ontology highlight
ABSTRACT:
SUBMITTER: Shen C
PROVIDER: S-EPMC4688131 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Molecular cell 20151125 6
The bromodomain and extraterminal (BET) protein BRD4 is a therapeutic target in acute myeloid leukemia (AML). Here, we demonstrate that the AML maintenance function of BRD4 requires its interaction with NSD3, which belongs to a subfamily of H3K36 methyltransferases. Unexpectedly, AML cells were found to only require a short isoform of NSD3 that lacks the methyltransferase domain. We show that NSD3-short is an adaptor protein that sustains leukemia by linking BRD4 to the CHD8 chromatin remodeler, ...[more]