History of oral contraceptive use and risk of spontaneous abortion.

ABSTRACT:

Purpose

To examine the association between pregravid oral contraceptive (OC) use and spontaneous abortion (SAB).

Methods

In an Internet-based preconception cohort study of 4862 Danish pregnancy planners, we used Cox proportional hazards models to estimate adjusted hazard ratios and 95% confidence intervals (CIs) for the association between OC use and SAB. We controlled for maternal age, physical activity, parity, education, alcohol and caffeine consumption, body mass index, and smoking.

Results

Compared with women who discontinued OCs >1 year before conception, HRs were 0.95 (95% confidence interval (CI) = 0.77-1.17), 0.99 (95% CI = 0.82-1.19), and 0.80 (95% CI = 0.60-1.06) for women who discontinued OCs 7-12, 2-6, and 0-1 months before conception, respectively. Compa

SUBMITTER: Hahn KA 

PROVIDER: S-EPMC4688154 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature