Inhibition of lipogenesis reduces inflammation and organ injury in sepsis.

ABSTRACT:

Background

Sepsis is a life-threatening acute inflammatory condition associated with metabolic complications. Accumulation of free fatty acids (FFAs) induces inflammation and causes lipotoxic effects in the liver. Because fatty acid metabolism plays a role in the inflammatory response, we hypothesized that the administration of C75, a fatty acid synthase inhibitor, could alleviate the injury caused by sepsis.

Methods

Male mice were subjected to sepsis by cecal ligation and puncture (CLP). At 4 h after CLP, different doses of C75 (1- or 5-mg/kg body weight) or vehicle (20% dimethyl sulfoxide in saline) were injected intraperitoneally. Blood and liver tissues were collected at 24 h after CLP.

Results

C75 treatment with 1- and 5-mg/kg body weight significantly lowered FF

SUBMITTER: Idrovo JP 

PROVIDER: S-EPMC4688159 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature