Prenatal perfluoroalkyl substance exposure and child adiposity at 8 years of age: The HOME study.

ABSTRACT:

Objective

To examine relationships between prenatal perfluoroalkyl substance (PFAS) exposure and adiposity in children born to women who lived downstream from a fluoropolymer manufacturing plant.

Methods

Data are from a prospective cohort in Cincinnati, Ohio (HOME Study). Perfluorooctanoic (PFOA), perfluorooctane sulfonic (PFOS), perfluorononanoic (PFNA), and perfluorohexane sulfonic (PFHxS) acids were measured in prenatal serum samples. Differences were measured in body mass index z-scores (BMI), waist circumference, and body fat at 8 years of age (n = 204) and BMI between 2-8 years of age (n = 285) according to PFAS concentrations.

Results

Children born to women in the top two PFOA terciles had greater adiposity at 8 years than children in the 1st tercile. For examp

SUBMITTER: Braun JM 

PROVIDER: S-EPMC4688224 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature