Impact of adiposity on cellular adhesion: The Multi-Ethnic Study of atherosclerosis (MESA).

ABSTRACT:

Objective

At the cellular level, how excess adiposity promotes atherogenesis is not fully understood. One pathway involves secretion of adipokines that stimulate endothelial dysfunction through increased expression of adhesion molecules. However, the relationship of adiposity to adhesion molecules that promote atherosclerosis is largely unknown.

Methods

Linear regression models were used to assess the sex-specific associations of soluble cellular adhesion molecules (sP- and sL-selectin, sICAM-1, sVCAM-1, and sHGF) and adiposity in 5,974 adults examined as part of the Multi-Ethnic Study of Atherosclerosis (MESA). Adiposity measures included body mass index (BMI), waist-to-hip-ratio (WHR), and computed tomography measures of subcutaneous adipose tissue (SAT) and visceral adipo

SUBMITTER: Christoph MJ 

PROVIDER: S-EPMC4688228 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature