Chronic Stress Decreases Cerebrovascular Responses During Rat Hindlimb Electrical Stimulation.

ABSTRACT: Repeated stress is one of the major risk factors for cerebrovascular disease, including stroke, and vascular dementia. However, the functional alterations in the cerebral hemodynamic response induced by chronic stress have not been clarified. Here, we investigated the in vivo cerebral hemodynamic changes and accompanying cellular and molecular changes in chronically stressed rats. After 3 weeks of restraint stress, the elicitation of stress was verified by behavioral despair in the forced swimming test and by physical indicators of stress. The evoked changes in the cerebral blood volume and pial artery responses following hindpaw electrical stimulation were measured using optical intrinsic signal imaging. We observed that, compared to the control group, animals under chronic restraint stre

SUBMITTER: Lee S 

PROVIDER: S-EPMC4688360 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature