Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis.

ABSTRACT:

Objective

To evaluate the effectiveness of replacing dietary saturated fat with omega 6 linoleic acid, for the secondary prevention of coronary heart disease and death.

Design

Evaluation of recovered data from the Sydney Diet Heart Study, a single blinded, parallel group, randomized controlled trial conducted in 1966-73; and an updated meta-analysis including these previously missing data.

Setting

Ambulatory, coronary care clinic in Sydney, Australia.

Participants

458 men aged 30-59 years with a recent coronary event.

Interventions

Replacement of dietary saturated fats (from animal fats, common margarines, and shortenings) with omega 6 linoleic acid (from safflower oil and safflower oil polyunsaturated margarine). Controls received no specific dietary in

SUBMITTER: Ramsden CE 

PROVIDER: S-EPMC4688426 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature