Tocolytic therapy for preterm delivery: systematic review and network meta-analysis.

ABSTRACT:

Objective

To determine the most effective tocolytic agent at delaying delivery.

Design

Systematic review and network meta-analysis.

Data sources

Cochrane Central Register of Controlled Trials, Medline, Medline In-Process, Embase, and CINAHL up to 17 February 2012.

Study selection

Randomised controlled trials of tocolytic therapy in women at risk of preterm delivery.

Data extraction

At least two reviewers extracted data on study design, characteristics, number of participants, and outcomes reported (neonatal and maternal). A network meta-analysis was done using a random effects model with drug class effect. Two sensitivity analyses were carried out for the primary outcome; restricted to studies at low risk of bias and restricted to studies excluding women

SUBMITTER: Haas DM 

PROVIDER: S-EPMC4688428 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature