Female Hormonal Factors and the Risk of Endometrial Cancer in Lynch Syndrome.

ABSTRACT:

Importance

Apart from hysterectomy, there is no consensus recommendation for reducing endometrial cancer risk for women with a mismatch repair gene mutation (Lynch syndrome).

Objective

To investigate the association between hormonal factors and endometrial cancer risk in Lynch syndrome.

Design, setting, and participants

A retrospective cohort study included 1128 women with a mismatch repair gene mutation identified from the Colon Cancer Family Registry. Data were analyzed with a weighted cohort approach. Participants were recruited between 1997 and 2012 from centers across the United States, Australia, Canada, and New Zealand.

Exposures

Age at menarche, first and last live birth, and menopause; number of live births; hormonal contraceptive use; and postmenopaus

SUBMITTER: Dashti SG 

PROVIDER: S-EPMC4688894 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature