BALR-6 regulates cell growth and cell survival in B-lymphoblastic leukemia.

ABSTRACT:

Background

A new class of non-coding RNAs, known as long non-coding RNAs (lncRNAs), has been recently described. These lncRNAs are implicated to play pivotal roles in various molecular processes, including development and oncogenesis. Gene expression profiling of human B-ALL samples showed differential lncRNA expression in samples with particular cytogenetic abnormalities. One of the most promising lncRNAs identified, designated B-ALL associated long RNA-6 (BALR-6), had the highest expression in patient samples carrying the MLL rearrangement, and is the focus of this study.

Results

Here, we performed a series of experiments to define the function of BALR-6, including several novel splice forms that we identified. Functionally, siRNA-mediated knockdown of BALR-6 in human B-AL

SUBMITTER: Rodriguez-Malave NI 

PROVIDER: S-EPMC4688921 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature