Part 1 - Coronary angiography with gadofosveset trisodium: a prospective feasibility study evaluating injection techniques for steady-state imaging.

ABSTRACT:

Background

The purpose of this study was to define an optimal injection protocol for 5-10 min duration navigator-based coronary MR angiography using an intravascular gadolinium-based contrast agent (GBCA), which is better suited for steady-state coronary MR angiography than conventional GBCAs.

Methods

Using projections from pharmacokinetic models of the intravascular concentration of gadofosveset, a dual-injection protocol was formulated and tested on 14 healthy human subjects. Modified Look-Locker inversion recovery (MOLLI) sequences were used for T1 mapping at 3 Tesla to evaluate the concentration of tracer in the aorta over the scanning interval.

Results

Pharmacokinetic models for a bolus plus slow infusion technique at a 5, 10, and 15 min steady state intravascula

SUBMITTER: Ahlman MA 

PROVIDER: S-EPMC4688989 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature