Salience Network Functional Connectivity Predicts Placebo Effects in Major Depression.

ABSTRACT:

Background

Recent neuroimaging studies have demonstrated resting-state functional connectivity (rsFC) abnormalities among intrinsic brain networks in Major Depressive Disorder (MDD); however, their role as predictors of treatment response has not yet been explored. Here, we investigate whether network-based rsFC predicts antidepressant and placebo effects in MDD.

Methods

We performed a randomized controlled trial of two weeklong, identical placebos (described as having either "active" fast-acting, antidepressant effects or as "inactive") followed by a ten-week open-label antidepressant medication treatment. Twenty-nine participants underwent a rsFC fMRI scan at the completion of each placebo condition. Networks were isolated from resting-state blood-oxygen-level-dependent si

SUBMITTER: Sikora M 

PROVIDER: S-EPMC4689203 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature