Targeting the Wnt signaling pathways in pulmonary arterial hypertension.

ABSTRACT: Pulmonary arterial hypertension (PAH) is a life-threatening disorder that is associated with elevated pulmonary pressures and right heart failure resulting from progressive loss and thickening of small pulmonary arteries. Despite their ability to improve symptoms, current therapies fail to prevent disease progression, leaving lung transplantation as the only therapy in end-stage PAH. To overcome the limitations of current therapies, there is an active search for disease-modifying agents capable of altering the natural history of, and improving clinical outcomes in, PAH. The Wnt signaling pathways have emerged as attractive treatment targets in PAH given their role in the preservation of pulmonary vascular homeostasis and the recent development of Wnt-specific compounds and biological thera

SUBMITTER: de Jesus Perez V 

PROVIDER: S-EPMC4689294 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature