Interleukin-10 inhibits chronic angiotensin II-induced pathological autophagy.

ABSTRACT:

Background

Although autophagy is an essential cellular salvage process to maintain cellular homeostasis, pathological autophagy can lead to cardiac abnormalities and ultimately heart failure. Therefore, a tight regulation of autophagic process would be important to treat chronic heart failure. Previously, we have shown that IL-10 strongly inhibited pressure overload-induced hypertrophy and heart failure, but role of IL-10 in regulation of pathological autophagy is unknown. Here we tested the hypothesis that IL-10 inhibits angiotensin II-induced pathological autophagy and this process, in part, leads to improve cardiac function.

Methods and results

Chronic Ang II strongly induced mortality, cardiac dysfunction in IL-10 Knockout mice. IL-10 deletion exaggerated pathological au

SUBMITTER: Kishore R 

PROVIDER: S-EPMC4689660 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature