A Meta-Analysis of the Association between Polymorphisms in MicroRNAs and Risk of Ischemic Stroke.

ABSTRACT: Ischemic stroke (IS) is responsible for a high death rate and for adult disability worldwide. MiR-146a (rs2910164), miR-149 (rs2292832), miR-196a2 (rs11614913) and miR-499 (rs3746444) are found to be associated with ischemic stroke. However, the results were inconsistent and inconclusive. The present study performed a meta-analysis to get a more precise and comprehensive estimation of the association between the four polymorphisms and IS risk. The databases Pubmed, Embase, Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure, and Chinese Biomedical Literature Database were searched for related studies. A total of five studies including 2230 cases and 2229 controls were identified for the meta-analysis. The results indicate that TT genotype and T allele

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC4690041 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature