Potential public health impact of RTS,S malaria candidate vaccine in sub-Saharan Africa: a modelling study.

ABSTRACT:

Background

Adding malaria vaccination to existing interventions could help to reduce the health burden due to malaria. This study modelled the potential public health impact of the RTS,S candidate malaria vaccine in 42 malaria-endemic countries in sub-Saharan Africa.

Methods

An individual-based Markov cohort model was constructed with three categories of malaria transmission intensity and six successive malaria immunity levels. The cycle time was 5 days. Vaccination was assumed to reduce the risk of infection, with no other effects. Vaccine efficacy was assumed to wane exponentially over time. Malaria incidence and vaccine efficacy data were taken from a Phase III trial of the RTS,S vaccine with 18 months of follow-up (NCT00866619). The model was calibrated to reproduce the

SUBMITTER: Sauboin CJ 

PROVIDER: S-EPMC4690265 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature