Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm.

ABSTRACT:

Background

Studies in many model systems have shown that canonical signaling through the pathway downstream of ligands of the Wnt family can regulate multiple steps in organogenesis, including cell proliferation, differentiation, and lineage specification. In addition, misexpression of the Wnt-family member Wingless in Drosophila imaginal disc cells can lead to transdetermination of progenitors from one lineage to another. Conditional deletion of the beta-catenin component of the Wnt signaling pathway has indicated a role for Wnt signaling in mouse lung endoderm development. The full range of effects of this pathway, which includes the transcription factor Lef1, has not been explored, however.

Results

To explore this issue, we expressed a constitutively active beta-catenin-L

SUBMITTER: Okubo T 

PROVIDER: S-EPMC469027 | biostudies-literature | 2004

REPOSITORIES: biostudies-literature