Comparative analysis of blood and saliva expression profiles in chronic and refractory periodontitis patients.

ABSTRACT:

Background

This study aimed to identify characteristic representative genes through a comparative analysis of gene expression profiles in the blood and saliva of chronic periodontitis (CP) and refractory periodontitis (RP) patients to provide new treatment strategies that may be helpful in the treatment of different forms of periodontitis.

Methods

GSE43525 was downloaded from Gene Expression Omnibus. In the dataset, thirteen samples were from blood including 4 controls, 4 CP and 5 RP samples, and ten samples were from saliva including 3 controls, 4 CP and 3 RP samples. After comparing the CP and RP samples, differentially expressed genes (DEGs) between these two types of periodontitis in the blood and saliva samples were identified by an LIMMA package. Then, functional and p

SUBMITTER: Zhang B 

PROVIDER: S-EPMC4690408 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature