Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF.

ABSTRACT: Mono-, di- and trimethylated states of particular histone lysine residues are selectively found in different regions of chromatin, thereby implying specialized biological functions for these marks ranging from heterochromatin formation to X-chromosome inactivation and transcriptional regulation. A major challenge in chromatin biology has centred on efforts to define the connection between specific methylation states and distinct biological read-outs impacting on function. For example, histone H3 trimethylated at lysine 4 (H3K4me3) is associated with transcription start sites of active genes, but the molecular 'effectors' involved in specific recognition of H3K4me3 tails remain poorly understood. Here we demonstrate the molecular basis for specific recognition of H3(1-15)K4me3 (residues 1-1

SUBMITTER: Li H 

PROVIDER: S-EPMC4690523 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature