Ketoacid Supplementation Partially Improves Metabolic Parameters in Patients on Peritoneal Dialysis.

ABSTRACT:

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Background

A low protein diet supplemented with ketoacids has been shown to improve the metabolic profile, including insulin resistance, in patients with chronic kidney disease (CKD), but whether ketoacids alone exert similar effects is unknown. In this prospective randomized controlled trial, we aimed to evaluate the effects of ketoacid supplementation on insulin resistance, systemic inflammation, oxidative stress and endothelial dysfunction among 100 CKD patients undergoing peritoneal dialysis (PD). ♦

Methods

Patients from one Chinese PD center were randomly assigned to take ketoacids (12 tablets per day) (n = 50) versus a control group (n = 50) for 6 months in an open-label parallelarm design. Daily protein intake of 0.8 - 1.2 g/kg/d and daily energy i

SUBMITTER: Dong J 

PROVIDER: S-EPMC4690629 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature