Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage.

ABSTRACT:

Objective

With no effective therapies to attenuate cartilage degeneration in osteoarthritis (OA), the result is pain and disability. Activation of hedgehog (HH) signaling causes changes related to the progression of OA, with higher levels of Gli-mediated transcriptional activation associated with increased disease severity. To elucidate the mechanism through which this occurs, this study sought to identify genes regulated by HH signaling in human OA chondrocytes.

Methods

Using human OA cartilage samples, microarray analyses were performed to detect changes in gene expression when the HH pathway was modulated. Results were analyzed for differentially expressed genes, grouped into functional networks, and validated in independent samples. To investigate the effects of chondroc

SUBMITTER: Ali SA 

PROVIDER: S-EPMC4690757 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature