The role of aortic compliance in determination of coarctation severity: Lumped parameter modeling, in vitro study and clinical evaluation.

ABSTRACT: Early detection and accurate estimation of the extent of coarctation of the aorta (COA) is critical to long-term outcome. Peak-to-peak trans-coarctation pressure gradient (PKdP) higher than 20mmHg is an indication for interventional/surgical repair. Patients with COA have reduced proximal and distal aortic compliances. A comprehensive study investigating the effects of variations of proximal COA and systemic compliances on PKdP, and consequently on the COA severity evaluation has never been done. This study evaluates the effect of aortic compliance on diagnostic accuracy of PKdP. Lumped parameter modeling and in vitro experiments were performed for COA severities of 50%, 75% and 90% by area. Modeling and in vitro results were validated against retrospective clinical data of PKdP, measured

SUBMITTER: Keshavarz-Motamed Z 

PROVIDER: S-EPMC4690767 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature