Injury-Mediated Vascular Regeneration Requires Endothelial ER71/ETV2.

ABSTRACT:

Objective

Comprehensive understanding of the mechanisms regulating angiogenesis might provide new strategies for angiogenic therapies for treating diverse physiological and pathological ischemic conditions. The E-twenty six (ETS) factor Ets variant 2 (ETV2; aka Ets-related protein 71) is essential for the formation of hematopoietic and vascular systems. Despite its indispensable function in vessel development, ETV2 role in adult angiogenesis has not yet been addressed. We have therefore investigated the role of ETV2 in vascular regeneration.

Approach and results

We used endothelial Etv2 conditional knockout mice and ischemic injury models to assess the role of ETV2 in vascular regeneration. Although Etv2 expression was not detectable under steady-state conditions, its expres

SUBMITTER: Park C 

PROVIDER: S-EPMC4690812 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature