Development of Phage Lysin LysA2 for Use in Improved Purity Assays for Live Biotherapeutic Products.

ABSTRACT: Live biotherapeutic products (LBPs), commonly referred to as probiotics, are typically preparations of live bacteria, such as Lactobacillus and Bifidobacterium species that are considered normal human commensals. Popular interest in probiotics has been increasing with general health benefits being attributed to their consumption, but there is also growing interest in evaluating such products for treatment of specific diseases. While over-the-counter probiotics are generally viewed as very safe, at least in healthy individuals, it must be remembered that clinical studies to assess these products may be done in individuals whose defenses are compromised, such as through a disease process, immunosuppressive clinical treatment, or an immature or aging immune system. One of the major safety cri

SUBMITTER: Dreher-Lesnick SM 

PROVIDER: S-EPMC4690888 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature