Association of PAEs with Precocious Puberty in Children: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Precocious puberty (PP) currently affects 1 in 5000 children and is 10 times more common in girls. Existing studies have tried to detect an association between phathalic acid esters (PAEs) and PP, but the results did not reach a consensus.

Objective

To estimate the association between PAEs and children with PP based on current evidence.

Methods

Databases including PubMed (1978 to March 2015), OVID (1946 to March 2015), Web of Science (1970 to March 2015), EBSCO (1976 to March 2015), CNKI (1979 to March 2015), WANFANG DATA (1987 to March 2015), CBM (1978 to March 2015) and CQVIP (1989 to March 2015) were searched to identify all case-control studies that determined the exposure and concentration of PAEs and their metabolites in children with PP. Meta-analysi

SUBMITTER: Wen Y 

PROVIDER: S-EPMC4690910 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature