IL-18 and Cutaneous Inflammatory Diseases.

ABSTRACT: Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-γ. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities.

SUBMITTER: Lee JH 

PROVIDER: S-EPMC4691115 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature