Proteins and Their Interacting Partners: An Introduction to Protein-Ligand Binding Site Prediction Methods.

ABSTRACT: Elucidating the biological and biochemical roles of proteins, and subsequently determining their interacting partners, can be difficult and time consuming using in vitro and/or in vivo methods, and consequently the majority of newly sequenced proteins will have unknown structures and functions. However, in silico methods for predicting protein-ligand binding sites and protein biochemical functions offer an alternative practical solution. The characterisation of protein-ligand binding sites is essential for investigating new functional roles, which can impact the major biological research spheres of health, food, and energy security. In this review we discuss the role in silico methods play in 3D modelling of protein-ligand binding sites, along with their role in predicting biochemical func

SUBMITTER: Roche DB 

PROVIDER: S-EPMC4691145 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature