Epigenetics of Aging and Alzheimer's Disease: Implications for Pharmacogenomics and Drug Response.

ABSTRACT: Epigenetic variability (DNA methylation/demethylation, histone modifications, microRNA regulation) is common in physiological and pathological conditions. Epigenetic alterations are present in different tissues along the aging process and in neurodegenerative disorders, such as Alzheimer's disease (AD). Epigenetics affect life span and longevity. AD-related genes exhibit epigenetic changes, indicating that epigenetics might exert a pathogenic role in dementia. Epigenetic modifications are reversible and can potentially be targeted by pharmacological intervention. Epigenetic drugs may be useful for the treatment of major problems of health (e.g., cancer, cardiovascular disorders, brain disorders). The efficacy and safety of these and other medications depend upon the efficiency of the pharm

SUBMITTER: Cacabelos R 

PROVIDER: S-EPMC4691177 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature