A comparison of iopromide and iopamidol, two acidoCEST MRI contrast media that measure tumor extracellular pH.

ABSTRACT: Acidosis within tumor and kidney tissues has previously been quantitatively measured using a molecular imaging technique known as acidoCEST MRI. The previous studies used iopromide and iopamidol, two iodinated contrast agents that are approved for clinical CT diagnoses and have been repurposed for acidoCEST MRI studies. We aimed to compare the performance of the two agents for measuring pH by optimizing image acquisition conditions, correlating pH with a ratio of CEST effects from an agent, and evaluating the effects of concentration, endogenous T1 relaxation time and temperature on the pH-CEST ratio correlation for each agent. These results showed that the two agents had similar performance characteristics, although iopromide produced a pH measurement with a higher dynamic range while iop

SUBMITTER: Moon BF 

PROVIDER: S-EPMC4691225 | biostudies-literature | 2015 Nov-Dec

REPOSITORIES: biostudies-literature